Currently r3 supports 1 DB per instance. Schemas within the 1 DB are used to separate name spaces for r3 applications.
If your tenants are completely separate, you can run multiple REI3 instances on the same server on different ports, using different databases. We do this as well with haproxy to forward multiple hostnames on port 443 to the same system.
If your tenants need to share data, you can use a single instance and separate access via policies.
What is your use case? Are tenants sharing data or are they completely separate and it´s only about hosting multiple tenants with the same system?